Georg von Segesser practices as independent arbitrator. He has acted as chairman, co-arbitrator, sole arbitrator and counsel in over two hundred domestic and international arbitrations (ICC, ICSID, Swiss Rules, DIS, VIAC, LCIA, SCC, UNCITRAL and others) and as co-director of the Claims Resolution Tribunal for Dormant Accounts in Switzerland. He is an arbitrator of the Court of Arbitration for Sport. His arbitration practice covers a broad range of issues, among them disputes related to joint ventures, mergers and acquisitions, distributorships, oil and gas, construction, building and manufacturing contracts, service and cooperation agreements and intellectual property rights.

Georg von Segesser has authored publications on international arbitration, property and trust law, and cultural and art law. He is a member of the Swiss Arbitration Association, the International Bar Association, the London Court of International Arbitration, the German Institution of Arbitration, the Chartered Institute of Arbitrators (Fellowship), the International Centre for Dispute Resolution of the American Arbitration Association, and arbitration institutions in England, Austria, Singapore, Kuala Lumpur, Brunei, and Hong Kong, etc. He is a past President of the International Academy of Estate and Trust Law.

In 1971, Georg von Segesser graduated from Zurich University. After serving as a district court clerk in 1971–72, he worked as an associate and partner at Pestalozzi & Gmür in Zurich from 1973 until 1982, and in 1974–75 as a foreign associate with Winthrop, Stimson, Putnam & Roberts in New York. In 1982, Georg von Segesser co-founded the law firm in Zurich which is now Schellenberg Wittmer Ltd and became of counsel in 2015. In 2017, Georg von Segesser opened von Segesser Law Offices and continues to practice as independent arbitrator.